This essay introduces our strategy of using combinations of therapies directed at all aspects of the malignant process, appropriate for each cancer type, to substantially reduce cancer related deaths. This strategy is based on the understanding that cancer is the result of intersecting webs of biological activity for the cancer cells, their microenvironment and systemic networks affecting the cancer. Effective treatment must damage the end result of these webs sufficiently so that their overall malignant properties cannot continue. This typically cannot be achieved by a single drug.
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